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Research and Clinical Trials

Discovering and Delivering Compassionate, Coordinated Care

At UMass Memorial Cancer Center of Excellence in Worcester, MA, we work in partnership with the University of Massachusetts Medical School to research new treatments for cancer. UMass Memorial is at the forefront of some of the nation’s most promising research and treatment programs. Through our Cancer Center Clinical Research Office (CRO), we perform breakthrough research and clinical trials to improve treatment and your quality of life.

Lung Cancer Trials Underway

CALGB 30610 
Stage III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide
INVESTIGATOR: Vijay Kasturi, MD
SPONSOR: Cancer and Leukemia Group B
CALGB 30610 at clinicaltrials.gov

CALGB 140503
A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (≤ 2cm) Peripheral Non-Small Cell Lung Cancer
INVESTIGATOR:  Karl Fabian Uy, MD
SPONSOR:  CALGB (Cancer and Leukemia Group B)
CALGB 140503 at clinicaltrials.gov

ECOG 1505

A Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Patients with Completely Resected Stage IB (>/= 4cm) - IIIA Non-Small-Cell Lung Cancer (NSCLC)
INVESTIGATOR: William Walsh, MD
SPONSOR: Eastern Cooperative Oncology Group
ECOG 1505 at clinicaltrials.gov

ECOG 5508
Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non Squamous NSCLC
INVESTIGATOR:  William Walsh, MD
SPONSOR:  NCI/Eastern Cooperative Oncology Group
ECOG 5508 at clinicaltrials.gov

Montefiore (UM200703)
A Randomized Phase II Study of Schedule-Modulated Concomitant Pemetrexed (Alimta) and Erlotinib (Tarceva) versus Single Agent Pemetrexed (Alimta) in Patients with Progressive or Recurrent Non-Small Cell Lung Cancer (NSCLC) 
INVESTIGATOR: William Walsh, MD
SPONSOR: Montefiore Medical Center
Montefiore at clinicaltrials.gov

GSK MAGRIT
A Double-Blind, Randomized, Placebo-Controlled Phase III Study to Assess the Efficacy of rec MAGE-A3 + AS15 Antigen-Specific Cancer Immunotherpeutic as Adjuvant Therapy in Patients with Resectable MAGE-A3-Positive Non-Small Cell Lung Cancer
INVESTIGATOR:  Syed Quadri, MD
SPONSOR: GlaxoSmithKline Pharmaceutical
GSK MAG RIT at clinicaltrials.gov

Learn more about research and other clinical trials underway at the UMass Memorial Cancer Center of Excellence.

Lung Cancer Studies Recruiting:
To learn more about clinical trials and cancer research,
call 508-856-3216 or email cancer.research@umassmed.edu